One‐Handed Helical Tubular Ladder Polymers for Chromatographic Enantioseparation**

Fully conjugated ladder polymers

Fully conjugated ladder polymers (cLPs), in which all the backbone units on the polymer main-chain are π-conjugated and fused, have attracted great interest owing to their intriguing properties, remarkable chemical and thermal stability, and potential suitability as functional organic materials. The synthesis of cLPs can be, in general, achieved by two main strategies: single-step ladderization...

Molecularly Imprinted Polymers for the Enantioseparation of Methylephedrine Chiral Drug

In this study molecular imprinting technology was employed to prepare a specific affinity sorbent for the resolution of Methylephedrine, a chiral drug. The molecularly imprinted polymer (MIP) was prepared by non-covalent molecular imprinting with either (+) or (-)-Methylephedrine ((R*,S*)-2-(methylamino)-1phenylpropan-1-ol) as the template. Methacrylic acid and ethylene glycol di-methacrylate w...

Mining Chromatographic Enantioseparation Data Using Matched Molecular Pair Analysis.

We apply matched molecular pair (MMP) analysis to data from ChirBase, which contains literature reports of chromatographic enantioseparations. For the 19 chiral stationary phases we examined, we were able to identify 289 sets of pairs where there is a statistically significant and consistent difference in enantioseparation due to a small chemical change. In many cases these changes highlight en...

Poly(iminomethylenes): Rigid Rod Helical Polymers

Poly(iminomethylenes): Rigid Rod Helical Polymers